CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Nutrition from the School of Applied Sciences of the State University of Campinas (FCA-UNICAMP) in 2020. She did a scientific initiation in Biochemistry and Molecular Biology between 2015 and 2018. She took her doctorate at the State University of Campinas, developing the project: "Unraveling the mechanisms of chemoresistance mediated by the KEAP1/NRF2 axis and the role of natural compounds in the treatment of lung and prostate cancer", funded by the São Paulo Research Foundation (FAPESP). In 2023, she worked as a visiting doctoral student for 12 months at New York University (NYU), funded by FAPESP. Currently, she is a postdoctoral fellow at the National Laboratory of Biosciences at the National Center for Research in Energy and Materials (LNBio, CNPEM) on a project involving "Glutaminase 1 and the remodeling of the immune microenvironment in triple negative breast cancer". (Source: Lattes Curriculum)
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The relationship between tumor cells and their microenvironment governs essential aspects of tumor biology, including therapeutic response and clinical prognosis. Immune cells-whether myeloid or lymphoid-interact with tumor cells, but their actions can be suppressed by potent immunosuppressive mechanisms. Immune function is also impacted by tumor metabolism, as cancer cells rapidly deplet…
Nrf2 (Nuclear factor erythroid 2-related factor 2) protein is considered one of the major regulators of oxidative stress and, once activated, triggers important changes in the expression of several genes involved in redox homeostasis, drug and cell metabolism, survival, proliferation, autophagy, proteasome degradation, DNA repair and mitochondrial biology. Several studies describe a preve…
mTOR pathway has been suggested as a central mechanism that converges different signaling pathways to coordinate cell growth and is commonly reported overactivated in cancer. Once activated by growth factors, amino acids, or energy (ATP/AMP ratio), mTOR induces the cap-dependent translation and ribosome biogenesis, increasing protein synthesis and other anabolic processes. mTOR is respons…
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