Abstract
The Autoimmune regulator (Aire) gene (human chromosome 21q22.3 and murine Mus musculus 10qC1), is a controller of central immune tolerance and of the emergence of autoimmune diseases. The Aire sequence shows ~ 80% man-mouse similarity and this gene regulates the transcription of Peripheral Tissue Antigens (PTAs) genes in medullary Thymic Epithelial Cells (mTECs). This phenomenon was calle…