Abstract
Macrophages are the most abundant immune cell type in the tumor microenvironment (TME) of head and neck squamous cell carcinomas (HNSCC), representing up to 50% of the tumor mass. The intensity of macrophage infiltration is inversely proportional to prognosis and disease survival. In the TME, macrophages are called tumor-associated macrophages (TAM) and their phenotype is determined by mo…