Abstract
Short-Chain Fatty Acids (SCFAs) from the fermentation of fiber-rich diets by the intestinal microbiota play important modulatory functions in the intestinal epithelium. These metabolites regulate genes involved in the energy metabolism of Intestinal Epithelial Cells (IECs) by stimulating oxygen consumption and, consequently, the activation of Hypoxia-Inducible Factor (HIF). Several studie…