Abstract
The aim of this study is test the hypothesis that dental pulp stem cells (DPSC) differentiate into vascular endothelial cells through regulation of Wnt/B-catenin ligands LRP6 or Frizzled6. DPSC will be transduced with EGFP-tagged lentiviral sh-RNA vectors (LRP6, Frizzled6 or empty vector) for experiments. Frizzled6 and LRP6 effects will be evaluated by GSK-3beta and Beta-catenin expressio…