Abstract
The occlusion of a coronary artery by a thrombus generated over a ruptured atherosclerotic plaque is the main cause of myocardial infarction. Although reperfusion is necessary to improve patients' recovery, it is paradoxically agent of ischemic injury. The mitochondrial permeability transition pore (MPT) plays a pivotal role in the ischemia-reperfusion injury (IRI). Therefore, the inhibit…