Abstract
Loxoscelism is the clinical condition caused by the bite of spiders of the genus Loxosceles, whose most common symptom is dermonecrosis. Enevnoming by brown spiders can cause more severe symptoms such as intravascular hemolysis, intravascular coagulation and impaired renal function, the main cause of death. Sphingomyelinase D (SMase D) is the key component, present in the venom and respon…