Carlos Roberto Jorge Soares

• Abstract

  The human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by cells in the chorionic syncyotrophoblast tissue, a portion of the placenta, during the pregnancy. The average molecular mass of hCG is 37.18 kDa, and corresponds to two subunits, ± and ², of 92 and 145 amino acid residues, respectively, added of glycans, covalently linked. The ± subunit (common for hTSH, hFSH and…

  Synthesis of recombinant human chorionic gonadotrophine in CHO and HEK-293 cells, purification and physicochemical characterization, AP.R

• Abstract

  The great majority of the recombinant proteins for farmaceutical use is glycosylated and it has, therefore, one more potential glycosylation sites, not always occupied. The importance of the carbohydrate moiety of a glycoprotein is well known and it is directly related to solubility, stability, folding, assembling, circulatory half-life and in-vivo biological activity. Only recently, howe…

  Glycoprofiling and N-glycosylation site occupancy of different human thyrotropin (hTSH) preparations of pituitary or recombinant origin, AP.R

• Abstract

  Recently the entity Food and Drug Administration (FDA) approved the commercial use in the United States of bromocriptine mesylate (trade name Cycloset®) to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). Cycloset® represents a new class of drugs to treat T2DM and acts as an agonist of dopamine D2 receptors. It is worth noting that many studies have also demonstrat…

  Evaluation of the potential of prolactin antagonists to the treatment of obesity and Diabetes mellitus 2, AP.R

(Only some records are available in English at this moment)

• Abstract

  The Arapaima gigas (Pirarucu) is a fish of the family of Osteoglossiformes, naturally Brazilian that is on exploitation according to IBAMA due to its predatory fishing and illegal trade. Your difficulty in captive breeding makes it possible to study the possible administration of recombinant gonadotropic hormones (FSH, LH and TSH) in order to stimulate their reproduction under breeding co…

  Obtention and characterization of cDNA corresponding to the beta subunit of pirarucu thyroid stimulating hormone (TSH) (Arapaima gigas), BP.IC

• Abstract

  iN 1986, Interferon was the first drug to demonstrate beneficial effects in patients with hepatitis C. Currently, all of hepatitis C treatments are based on the use of combined preparations of IFN-± with or without ribavirin. The therapy results in rapid decline of hepatitis C virus levels in the serum and, in long term, its extinction occurs in blood and liver. The alpha-2 interferon (IF…

  Development of fermentation in a bioreactor for the production of interferon ±-2a secreted into the periplasmic space of Escherichia coli, BP.MS