CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Rodrigo is a PhD student in the Graduate Program (PPG) in Functional and Molecular Biology at the Institute of Biomedical Sciences of the University of São Paulo (ICB-USP). By the same program, he obtained a MSc degree (2025 - Area: Physiology and Pharmacology), having been awarded an Research Internship Abroad (BEPE) scholarship from FAPESP, developing studies at the Division of Cell Biology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town (South Africa). He graduated in Biomedical Sciences at ICB-USP (2022), and was a Scientific Initiation scholarship holder from CNPq (2019-2020) and FAPESP (2020-2022). His work essentially consists of two fronts: i) the development of formulations for the delivery of seriniquinone, a natural marine product that is a candidate for antineoplastic and antifungal drugs, using nanotechnology and tissue engineering strategies in his studies and ii) understanding the role of dermicidin as a pharmacological target of seriniquinone in melanoma. (Source: Lattes Curriculum)
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Seriniquinone (SQ) and its derivatives comprise a group of substances with potent cytotoxic activity, showing selectivity for melanoma cell lines. These substances have presented a novel and distinct mechanism of action when compared to other quinones, through binding to dermcidin (DCD) and triggering autophagocytosis and apoptosis. One of the challenges for the advancement of SQ in the s…
Melanoma is one of the most aggressive cancers with increasing incidence, therapies that confer resistance and various adverse effects. Novel drugs with different therapeutic targets and mechanisms of action consist in an attempt to overcome these barriers. In this context, seriniquinone (SQ), synthesized by a rare Gram-positive marine bacterium from the genus Serinicoccus, was described …
Seriniquinone (SQ) and its derivatives are unique dermcidin (DCD) modulators. This protein seems to be involved in a range of cancer-related processes, including cell survival, migration, and cachexia. Despite its potential as a drug candidate, based on its promising in vitro efficacy data, little is known about the mechanism of action of SQ and the involvement of DCD in cancer biology. M…
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