Moises Ricardo de Almeida Barros in research grants and scholarships supported by FAPESP.
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All RNAs transcribed in eukaryotic cells undergo maturation stages. One of the steps that pre-mRNAs go through is the splicing process, where the non-coding sequences (introns) are removed and the coding sequences (exons) joined. For this process to occur, two transesterification reactions are necessary, which in turn are mediated by a multimeric complex called a spliceosome, composed of …
Splicing is a maturation process of pre-mRNAs, essential in eukaryotes, through which intron sequences are extracted from the precursor mRNAs, allowing the ligation of the exons and the formation of the protein coding sequences. Over a hundred factors are involved in this process, and among them, the protein Cwc24, which binds the intron 5'-end, protecting it from premature nucleophilic a…
The spliceosome is a large RNA-protein complex responsible for catalyzing the splicing reactions of pre-RNAs in eukaryotes. The spliceosome protein Cwc24 plays an important role in splicing regulation by binding the 5' splicing site (5'SS), and protecting this site from premature reactions. Our laboratory has shown that Cwc24 is a general splicing factor and that splicing of U3 snoRNA is …
| 1 / 1 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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