Abstract
Calcium ions are central for excitation-contraction coupling in skeletal muscle. A new mechanism proposed to regulate skeletal muscle Ca2+-handling is the generation of Ca2++mobilizing messengers derived from NAD, such as ADP-ribose (ADPR) and cyclic ADP-ribose (cADPR). Different studies have shown that: cADPR generation is increased in muscle during exercise; that cADPR can increase free…