Abstract
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine released by macrophages in the immune- inflammatory response, with a role in induction cell proliferation, migration and differentiation of dental pulp cells. This study aims to evaluate the hypothesis that TNF-alpha signaling via TNFR1 results in inhibition of mineralization, while signaling via TNFR2 leads to cell differentiation. Th…