Abstract
The naked DNA vaccine enconding the heat-shock protein of 65 kDa of Mycobacterium leprae presents a prophylactic and therapeutic effect in an experimental model of tuberculosis. Some results also showed that after intramuscular immunization, DNA-hsp65 could be detected in dendritic cells and lymphocyte B, from lymph node and bone marrow, suggesting B cells can also participate as APC in i…