Associate Professor of Pharmacology, UNESP, Botucatu, Sao Paulo, Department of Pharmacology. Pharmacist (2002). Master (2004) and PhD (2007) in Pharmacology (USP, Ribeirão Preto, Sao Paulo). Postdoctoral Research Fellow at Department of Pharmacology (USP, 2009) and at Harvard Medical School (2016). Adviser of masters and PhD students, Biological Sciences Program (Area: Pharmacology and Biotechnology, UNESP, Botucatu, Sao Paulo). The main focus is cardiovascular pharmacology. (Source: Lattes Curriculum)
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Preeclampsia (PE) is a disease that occurs in pregnancy and is characterized by elevated maternal blood pressure accompanied by endothelial dysfunction. Its pathogenesis is still not well understood; however, placental ischemia and hypoxia has shown importance in pathophysiology. In PE there is an increase in oxidative stress, increases in antiangiogenic factors and decreases in vasodilat…
Hypertensive disorders of pregnancy are characterized by an increase in systemic blood pressure. Preeclampsia is considered the most severe of these disorders and is usually accompanied by proteinuria and other clinical symptoms after the 20th gestational week. Perivascular adipose tissue (PVAT) may participate in the control of vascular tone through the release of vasoactive substances, …
Under gestation period, several cardiovascular adaptations must occur to maintain a healthy pregnancy. Preeclampsia (PE) is a disorder that occurs during pregnancy that is characterized by elevated maternal blood pressure (140x90mmHg) accompanied by proteinuria in 24-hour urine after the 20th week of pregnancy. Its pathogenesis is still unclear; however, the placenta seems to play a key r…
Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to isoflurane or sevoflurane. The alkaline single-cell gel electrophoresis …
(Only some records are available in English at this moment)
The gestational period is marked by several systemic adaptations, including cardiovascular, necessary for the development of a healthy pregnancy, meeting the fetal metabolic demand.Preeclampsia (PE) is a condition that occurs during pregnancy in which trophoblastic invasion and the formation of blood vessels at the maternal-fetal interface are impaired by factors that are still unclear. T…
The gestational period is marked by several systemic adaptations, including cardiovascular, necessary for a healthy pregnancy, meeting the fetal metabolic demand. Pre-eclampsia (PE) is a complication of pregnancy with pathogenesis that is still unclear, but it is characterized by elevated maternal blood pressure. In a healthy pregnancy there is a normal trophoblastic invasion and formatio…
Although there were great advances in the diagnosis and treatment of hypertension during pregnancy, such conditions are still among the highest causes of maternal and perinatal morbidity and mortality worldwide. Nitric oxide (NO) derived from the endothelial nitric oxide synthase (eNOS) enzyme and matrix metalloproteinases (MMP-2 and MMP-9), play important roles in the vascular endotheliu…
(Only some records are available in English at this moment)
Pre-eclampsia is a gestational hypertensive disorder characterized by systolic and diastolic blood pressure commonly greater than 140/90 mmHg and which usually appears after the 20th week of pregnancy. Studies suggest increases in oxidative stress and antiangiogenic factors in pre-eclampsia with a concomitant reduction in vasodilator mediators and deficient placentation, which are accompa…
Hypertensive disorders of pregnancy are the main causes of maternal and fetal mortality, characterized by elevations in maternal blood pressure which may compromise fetal development. The pathogenesis is still unknown, but there are theories that there is a decrease in the plasticity of the vessels of the maternal-fetal interface, placental ischemia accompanied by maternal endothelial dys…
Preeclampsia is featured by increases in systolic and diastolic blood pressures, often followed by proteinuria after the 20th gestational week. Theories suggest that preeclampsia may be caused by poor placentation and that this diminishes the elasticity of the maternal-fetal interface vessels, impairing blood flow to the uterus and that may cause placental hypoperfusion and ischemia, whic…
(Only some records are available in English at this moment)
Preeclampsia affects 5-8% of pregnancies and is characterized by increased blood pressure and proteinuria from 20 weeks of gestation. These changes appear to be initially related to placental ischemia, causing insufficient uteroplacental oxygenation followed by increased release of anti-angiogenic factors such as sFlt-1 (soluble fms-like tyrosine kinase-1, which is a soluble VEGF receptor…
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
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CV Lattes
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