Abstract
Osteosarcoma is a locally aggressive bone neoplasm, highly metastatic, and with an unfavorable prognosis. It represents 80% of canine malignant bone tumors, more frequent in large males, and with an average age of seven and a half years. By sharing multiple biological aspects with human osteosarcoma, the dog is a good model of comparative oncopathology for genetic, epigenetic, and therape…