PhD Student in Biochemistry at the University of São Paulo (USP), holding a BSc in Chemistry (with emphasis in Biochemistry and Molecular Biology) from the same institution (2022).Works at the Chemistry-Biochemistry interface, investigating mechanisms of oxidative damage in DNA and proteins mediated by singlet oxygen. Primary research approach utilizes liquid chromatography coupled with mass spectrometry (LC-MS) for reactivity studies and proteomics. (Source: Lattes Curriculum)
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Singlet molecular oxygen (1O2) has been shown to be generated in biological systems. Biological targets for 1O2 include unsaturated fatty acids, proteins, and DNA. Preliminary results obtained in an undergraduate research project showed that 0.2 to 4 % of 6-thioguanine (6-TG) is incorporated in the DNA of HaCat epithelial cells. In this view, this research project aims to use 6-thioguanin…
The thiopurines azathioprine, 6-thioguanine (6-TG), and 6-mercaptopurine (6-MP) are used as immunosuppressors in transplanted patients, and for treatment of inflammatory diseases, such as rheumatoid arthritis and systemic lupus. These drugs are metabolized by the purine salvage pathway, converted into thioguanine nucleotides and then incorporated in DNA as 6-TG. Recent studies reveal that…
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