CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Medical graduation in the Federal University of São Paulo (1978). Obtained master's degree in the Department of Microbiology, Parasitology and Imunology from the same University(1986) and the PhD from the Department of Pathology of the University of São Paulo School of Medicine (1991). Academic appointment as Associate Professor in the Department of Pathology of the Federal University of São Paulo. Coordinator of the Biobank UNIFESP. Main research interest in cutaneous pathology, specially pigmented lesions, imuno-histochemistry and molecular pathology. Other interests: oncopathology and oral pathology (Source: Lattes Curriculum)
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BRAF, MEK and KIT point mutations are widely known for inducing resistance to targeted therapy in systemic treatment of advanced cutaneous melanoma. To explain this phenomenon different mechanisms are proposed, including tumoral genomic heterogeneity, both in primary and metastatic tumors. We have previously tested the heterogeneity hypothesis in primary cutaneous melanomas (acral lentigi…
Cutaneous melanoma is a malignant neoplasm arising from the uncontrolled proliferation of melanocytes skin. The acral lentiginous melanoma occurs in places not exposed to solar radiation, palms, soles and subungual areas, is more common in Asian and African descent, accounting for 2-3% of all melanoma cases. Studies that evaluate the signaling pathways in melanoma progression of this type…
Melanoma has its initiation in malignance transformation of melanocytes. Acral lentiginous melanoma (ALM) subtype was once thought to occur more often in more darkly pigmented races and it was also thought to have a more aggressive biologic nature than other subtypes. As the name implies, ALM occurs on acral surfaces, specifically the palms, soles, and nails. Genetics characteristics of t…
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