Abstract
Multiple Sclerosis (MS) is an inflammatory and autoimune disease of the Central Nervous System (CNS). The cytotoxic activity of T lymphocytes has been reported as an effector mechanism for MS development. Moreover, it has been shown that the presence of cytotoxic CD4+ T cells (CD4_CTLs) drives MS progression and that these cells contribute to MS lesions by targeting oligodendrocytes. In t…