Abstract
We have demonstrated that T3 induces to increased S100A8, a DAMP which activates TLR4/MyD88/NF-kB signaling pathway and essential to cardiac hypertrophy observed in the hyperthyroidism. This signaling pathway is critical to activate different intracellular sensors such as NLRP3, AIM2, NLRC4 and other inflammasomes. Beta-adrenergic stimulation also activates NF-kB, although there are no re…