CV Lattes
ORCID
Abstract
The molecular bases of monogenic hypercholesterolemia are associated with: 1. reduced activity of the low-density lipoprotein (LDLR) receptor, consequently with low LDL plasma clearance. 2. The conformational alterations of Apolipoprotein B 100 (ApoB-100), the main LDL protein, responsible for binding to the receptor, which alters affinity, which also leads to low plasma removal of LDL (A…