CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Lucas de Abreu Ferreira Machado in research grants and scholarships supported by FAPESP.
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The tumor microenvironment (TME) plays a crucial role in cancer progression and resistance to immunotherapy. This project aims to investigate the role of heme oxygenase-1 (HO-1) in regulating oxidative stress and ferroptosis in immunosuppressive cells within the TME, such as tumor-associated macrophages (TAMs) and regulatory T cells (Tregs). By exploring the HO-1-ferroptosis axis, we aim …
During the last decades, several therapeutic approaches that use the pharmacological induction of cell death by apoptosis have been developed for the treatment of cancer. Despite the efficiency of these therapies, eventually, the tumor cells develop intrinsic resistance to the drugs used in this process. Therefore, finding new ways to induce tumor cell death has great relevance. Given the…
Heme-oxygenase 1 (HO-1) is an enzyme responsible for catalyzing the degradation of heme, generating products such as carbon monoxide (CO), biliverdin and ferrous iron (Fe²z). The expression of HO-1 is found in several types of cancer. The catabolites released by the breakdown of heme confer antioxidant, anti-inflammatory, anti-apoptotic and cytoprotective properties to HO-1 that can be us…
| 1 / 1 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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