Abstract
In this project we will evaluate in Trypanosoma cruzi, the protozoan causing Chagas Disease, the role of phosphorylation of eIF2± in the response to different stresses and the activation of AMPK, sensor of the energy state of eukaryotic cells. During nutritional stress eIF2± is phosphorylated, decreasing protein synthesis, and leading to differentiation to the infective form of the parasi…