Abstract
LXRs (liver x receptors) are nuclear receptors that act as sensors of cholesterol levels in the body. LXRs play a crucial role in the regulation of lipids metabolism, transport and efflux. LXRs are found in two isoforms, LXRalpha and beta. LXRalpha is primarily found in intestine, liver, and adipose tissue, while LXRbeta is expressed in almost all cell types. Once bound to a ligant, LXRs…