Abstract
A single nucleotide polymorphism in the gene encoding the type 2 (D2) deiodase enzyme, DIO2 (rs225014), results in a single amino acid substitution of threonine (Thr) for alanine (Ala) at position 92 in the D2 protein (Thr92AlaD2) and is present in about 12 to 36% of the population. Studies in young Ala92-D2 female mice showed significant cognitive impairment accompanied by alterations in…