CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's degree in Biological Sciences (2021) from the Federal University of Pernambuco (UFPE). He is currently a PhD student in the Graduate Program in Biology of the Host-Pathogen Relationship at the Institute of Biomedical Sciences, University of São Paulo - ICB/USP. In the Laboratory of Antigen Targeting to Dendritic Cells (DC Lab.), under the guidance of Professor Silvia Beatriz Boscardin, develops her research in the areas of Immunology, Cellular and Molecular Biology, Antibody Production, Antigen Targeting and Animal Models (Cre-LoxP system), dividing her thesis in III Parts: STAT3 signaling in cDC1s and its ability to induce cytotoxic CD8+ T cells; the influence of sialic acid in modulating maturation of conventional dendritic cells and enhancing antigen responsiveness by CD4+ and CD8+ T cells after antigen targeting; targeting of the immunogenic protein PvMSP1(19)-PADRE encapsulated by polymeric nanoparticles to conventional dendritic cells (cDC1 and cDC2) in vivo. (Source: Lattes Curriculum)
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Splenic conventional Dendritic Cells (cDCs) are central in the process of inducing the immune response, as they are capable of presenting antigens from different pathogens and inducing the activation of naive T cells. In mice, splenic cDCs are often classified into cDC1 (expressing the alpha chain of the CD8 molecule and the endocytic receptor DEC205, CD8±+DEC205+) and into cDC2 (CD8± neg…
Conventional type 1 dendritic cells (cDC1s) play a pivotal role in orchestrating anti-tumor immunity by cross-presenting antigens and priming CD8¿ T cell responses. Our previous work, utilizing DEC205-mediated antigen targeting, demonstrated robust induction of antigen-specific CD8¿ T cells and effective tumor control in preclinical models. However, the contribution of STAT3 signaling wit…
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