Abstract
Crotoxin, the major component of venom from Crotalus snakes, is a heterodimeric complex that contains a phospholipase A2 (PLA2) and exerts a lethal action by blocking neuromuscular transmission. Crotoxin consists of a noncovalent association of an acidic, nonezymatic and nontoxic subunit, the crotapotin (or crotoxin A; CA) and a basic and toxic PLA2 subunit, the crotoxin B (CB). Crotalus …