Abstract
Mesial temporal lobe epilepsy (MTLE) is the most frequent form of refractory focal epilepsy in adults, and hippocampal sclerosis is its most common and widely studied pathological substrate. Hippocampal sclerosis is present in 60% to 70% of patients with MTLE who are indicated for surgery for failure of clinical treatment. Currently, special attention has been given to the neuronal damage…