Abstract
The development of tumors associated with HPV (Human Papillomavirus) is mainly due to persistent infections by oncogenic high-risk HPVs, and among them HPV-16 is the most prevalent worldwide in both pre-neoplastic lesions and cancers in different anatomical sites of men and women. High-risk HPV oncoproteins E6 and E7 associate and inactivate tumor suppressor proteins p53 and pRb respectiv…