Abstract
The osteocyte-osteoblast interactions affect bone repair and remodeling, which are relevant to theosseointegration of titanium (Ti) implants. We have demonstrated that Ti with nanotopography (Ti-Nano) generated by treatment with H2SO4 and H2O2 favors osteoblast differentiation by modulating several cell signaling pathways and attenuates the inhibitory effect of osteoclasts on osteoblast d…