Abstract
The second messenger cyclic bis-(3',5')-di-guanosine monophosphate (c-di-GMP) influences the regulation of several bacterial processes involved in virulence, such as biofilm formation. The synthesis and degradation of c-di-GMP occur due to two classes of proteins: diguanylate cyclases (DGCs), with active GGDEF domains; and phosphodiesterases (PDEs) with EAL or HD-GYP domains. The opportun…