Abstract
The orofacial cleft is the most common malformation in the face, with a prevalence between 0.36 and 1.54 per 1,000 live births in the Brazilian population. With a multifactorial etiology, nonsyndromic orofacial clefts are caused by interactions between environmental factors, such as smoking and medications, and genetic factors, with one of the most studied genes being the interferon regul…