Abstract
Acute Myeloid Leukemia (AML) is a severe hematologic malignancy characterized by blockage in myeloid differentiation and uncontrolled proliferation of leukemic cells that accumulate in the bone marrow and blood. The TP53 gene, known as "guardian of the genome" is an important tumor suppressor encoding the p53 protein, whose inactivation is related to increased proliferation, survival and …