Abstract
The renin-angiotensin system (RAS) is involved in physiological and pathological processes. Currently, a new paradigm has emerged where two main axes are believed to modulate SRA function: a deleterious axis composed of ACE/Ang II/AT1 receptor, and another beneficial axis composed of ACE2/Ang-(1-7)/MAS receptor. These functional aspects increase the range of possible targets for the treat…