Guilherme de Azevedo Carvalho

Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal)
Birthplace: Brazil

Abstract
Several pieces of evidence point to inflammation as a relevant phenomenon in Alzheimer's Disease (AD), promoting alterations in the beta-amyloid (A²) degradation process and in the induction of neuronal death. Studies indicate that microglial activation is involved in both processes. In AD, the presence of A² promotes the activation of microglia with the participation of the P2X7R recepto…
Inhibition of the P2X7 purinergic receptor in microglia-mediated neuroinflammation in the in vivo model of Alzheimer's disease and its possible correlation with GSK3, BP.IC
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease whose incidence tends to increasewith the increase in the life expectancy of the world population, constituting the main form ofdementia among the elderly. To date, there are no effective therapeutic alternatives for thisillness. Beta-amyloid peptide oligomers (ABOs) are considered the mainneurotoxins involved in several deleterious …
Role of the P2X7 purinergic receptor in microglia-mediated neurotoxicity in models of Alzheimer's disease and its possible correlation with the modulation of neurogenesis, BP.IC

CV Lattes ORCID

2 / 2	Completed scholarships in Brazil

Associated processes