Abstract
Stage 3-4 Grade C periodontitis in young people (Perio4C) is a rapidly progressive disease triggered by an imbalance in the host's immune response to the subgingival dysbiotic microbiota, which may be related to the interaction of periodontal pathogens in the biofilm with the cells of the epithelium of the gingival sulcus and adjacent connective tissue, which, by undergoing epigenetic mod…