Abstract
Diarrheal disease is one of the main public health problems worldwide, causing about 1.5 million deaths annually in children under five years of age, and about 30 to 40% of episodes of acute diarrhea in the world are caused by diarrheagenic Escherichia coli, with emphasis on the pathotype responsible for acute diarrhea/traveller's diarrhea, enterotoxigenic E. coli (ETEC). ETEC produces th…