Abstract
Futile metabolic cycles composed of antagonic processes such as fatty acids de novo synthesis and ²-oxidation are activated simutaneoulsy with brown adipose tissue UCP-1 and thermogenesis. Thus, it is our goal in this proposal to invetigate the signaling pathways regulating fatty acids de novo synthesis and ²-oxidation in brown adipose tissue with a special focus on the role of mTORC2 and…