Abstract
Myeloproliferative neoplasms (MPN) are clonal diseases from the hematopoietic stem cells, with increased proliferation of the myeloid series (granulocytic, erythrocytic, megakaryocytic series or mast cells) with effective maturation. The mutations involved in the pathogenesis of the classical Philadelphia-negative MPN (polycythemia vera, primary myelofibrosis, and essential thrombocythemi…