Abstract
Intercellular communication is a key point in the polarization of macrophages towards the M1 and M2 subtypes. The M1 subtype has a pro-inflammatory profile while the M2 does not. Among the various changes that occur in cells and in the tumor microenvironment, we highlight the deregulation of sphingolipids. Recently, our group showed that the increase of sphingosine kinase 2 (SPHK2) in non…