Abstract
MTC in MEN2 shows different behaviors regarding local dependence and the type of RET gene mutation, causing different situations of MTC genesis, disease aggressiveness, and manifestations. Since the discovery of TKs inhibitors, such as vandetanib, cabozantinib, and new drugs, like LOXO-292 and BLU-667, there has been improvement in the treatment of advanced, progressive or symptomatic dis…