Abstract
Endothelial cells modulate vascular reactivity through the release of mediators such as nitric oxide and endothelin. The current dogma is that catecholamines modulate vascular tonus, cardiac chronotropism and inotropism through their release from adrenergic terminals, and with action on a and b adrenergic receptors. Using mass spectrometry, we identified basal release of endothelium-depen…