Abstract
The ubiquitin proteasome system (SUP) is primarily responsible for intracellular proteolysis in eukaryotes, consisting of 3 enzymes: E1 (ubiquitin-activating enzyme), E2 (ubiquitin-carrying enzyme) and E3s (ubiquitin-ligases), which recognize and transfer ubiquitin to the substrate, which may subsequently be destined for degradation via the proteasome. In mammals, the largest and best-stu…