Abstract
We have previously demonstrated that T3 induces to increased S100A8 levels, a DAMP involved with TLR4/MyD88/NF-kB signaling and important to cardiac hypertrophy observed in hyperthyroidism. This signaling pathway is critical to activation of intracellular sensors as NLRP3, AIM2, NLRC4 and inlammasome activation. On the other hand, beta-adrenergic stimulation also acts in the NF-kB signali…