Abstract
Mammalian spermatozoa require a last maturation step in the female reproductive tract to fertilize the egg. This remarkable physiological process, known as capacitation, prepares spermatozoa to undergo acrosome reaction (AR). At the molecular level, activation of the adenylyl cyclase/cyclic AMP/protein kinase A (AC/cAMP/PKA) pathway and phosphorylation cascades and hyperpolarization of th…