CV Lattes
ORCID
Abstract
Acute lymphoblastic leukemia (ALL) represents the most common type of cancer in childhood, accounting for a quarter of all childhood malignancies. Although approximately 80% of patients are cured, the main cause of treatment failure is resistance to drugs used during treatment. Methotrexate (MTX) is one of the main drugs used to combat ALL, as it inhibits nucleotide synthesis and induces …