Abstract
Acute myeloid leukemia (AML) is a neoplasia caused by blockage of myeloid hematopoietic cell differentiation and consequent accumulation of blasts in the bone-marrow. AML is characterized by low survival rates and the presence of TP53 gene mutations found in approximately 10% of the cases are related with worse prognosis. Moreover, dysregulation of the p53 signaling pathway is found in ad…