Abstract
Hemoglobin (Hb) is a tetramer hemeprotein found in high concentrations in erythrocytes, formed by a pair of ±-like chains and a pair of ²-like chains, each associated with a heme prosthetic group with a ferrous atom capable of reversibly binding. to oxygen. The HbO2 binding is mediated by several mechanisms, such as O2 pressure (PO2), H+/CO2 and 2,3-bisphosphoglycerate (2,3-BPG) and repre…