CV Lattes
ORCID
Abstract
Due to its metastatic and highly proliferative capacity, melanoma is the skin cancer with the highest mortality rate, although it is a minor incident. This scenario is mainly due to the waiting aspect in the MAPK pathway, mainly in the BRAFV600E protein, which exacerbates signals of growth, survival, invasion, and blocking of cell death. In this sense, the development of BRAF inhibitors (…