Abstract
The genus Flavivirus is composed of single-stranded positive-sense RNA genome viruses, comprising different viruses, such as dengue virus serotype 2 (DENV-2) and ZIKA virus (ZIKV), both of great importance in public health in Brazil. Flaviviruses are structurally similar, and this similarity is responsible for the induction of cross-reacting antibodies, which mainly target the envelope (E…