Abstract
At the Butantan Institute's Biopharmaceuticals Laboratory, 3 monoclonal antibodies (mAbs) were identified that, together, neutralize tetanus toxin in an in vivo study in mice. The result is compared to that obtained by equine hyperimmune polyclonal serum produced at Butantan, in a pharmacopeial test. The mAbs, expressed by transient transfection, were characterized by Western blot, ELISA,…